Epithalon: the complete guide
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from epithalamin, a pineal gland extract. It is studied primarily for telomerase activation and longevity effects.
How Epithalon works
Epithalon has been reported to stimulate telomerase activity and extend telomere length in cell studies, and to normalize melatonin secretion in aged subjects.
Typical Epithalon dosage
Commonly reported research ranges: 5–10 mg daily for short cycles (10–20 days), typically 2x yearly.
Dose should always be individualized. Factors that influence it include bodyweight, research goal, tolerance, and specific compound batch. The information below is educational, not a prescription.
How to reconstitute Epithalon
A widely used reconstitution for a 10 mg vial is 2 ml of bacteriostatic water. With a typical 5000 mcg dose this works out to the unit count shown in the calculator below.
Half-life and administration frequency
Short systemic half-life; biological effects reportedly longer.
This half-life informs how often Epithalon is typically dosed. Shorter half-lives usually mean more frequent dosing to maintain plasma levels; longer half-lives allow daily, weekly, or less-frequent administration depending on the compound.
Reported side effects
- Limited human safety data
- Generally well tolerated in short cycles
- Injection-site reactions
This list reflects effects reported in available literature or user logs. It is not exhaustive. Adverse reactions should be discussed with a qualified clinician.
Common Epithalon stacks
- Used alone in short, periodic cycles
Storage and handling
Lyophilized refrigerated. Reconstituted: refrigerated, use within 28 days.
FDA and regulatory status
Not FDA approved. Research use only.
Epithalon clinical trials and evidence
For clinical-trial and primary-literature context, start with the sources below. We prioritize official drug labels, ClinicalTrials.gov records, and PubMed-indexed literature when available.
- Epitalon clinical trial records — ClinicalTrials.gov
Track your Epithalon protocol on iPhone
Peptide Protocol logs every dose, calculates reconstitution for you, and keeps your full protocol on one calm screen.
See the app →Frequently asked questions
What is Epithalon?
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from epithalamin, a pineal gland extract. It is studied primarily for telomerase activation and longevity effects.
How does Epithalon work?
Epithalon has been reported to stimulate telomerase activity and extend telomere length in cell studies, and to normalize melatonin secretion in aged subjects.
What is a typical Epithalon dose?
Commonly reported ranges are 5–10 mg daily for short cycles (10–20 days), typically 2x yearly. This is research information, not a recommendation — dosing should be individualized under clinical guidance.
What is the half-life of Epithalon?
Short systemic half-life; biological effects reportedly longer. This influences how often it is administered.
How do you reconstitute Epithalon?
A common approach is to add 2 ml of bacteriostatic water to a 10 mg vial. Use the reconstitution calculator for exact unit counts.
What are the side effects of Epithalon?
Limited human safety data; Generally well tolerated in short cycles; Injection-site reactions.
Is Epithalon FDA approved?
Not FDA approved. Research use only.
Are there clinical trials for Epithalon?
Registered or published clinical-trial sources for Epithalon are listed in the references section below. Evidence depth varies widely by compound, so check the cited trial registries and primary literature before relying on any claim.
References
- Epitalon / epithalon literature (PubMed) — National Library of Medicine. Primary research on the Khavinson tetrapeptide and telomerase activity
- Khavinson et al. — Peptide epitalon aging and telomere research — PubMed. Foundational body of work from the research group that developed epitalon
- Epitalon clinical trial records — ClinicalTrials.gov. Very limited registered trials — most evidence is from Russian observational studies
Sources listed above were used to verify the claims on this page. See our editorial policy for how we source information.
Educational use only. Peptide Protocol is an informational tool. Nothing on this page constitutes medical advice. Many peptides are prescription-only or restricted in your jurisdiction. Always consult a licensed healthcare professional before injecting any compound.