Peptide Protocol
Peptide Protocol
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Peptide glossary

Research-grade overviews of the most-studied peptides. Each entry covers mechanism, typical dose, half-life, reconstitution, side effects, stacks, storage, and FDA status.

BPC-157

BPC-157 is a synthetic pentadecapeptide fragment of body protection compound found naturally in gastric juice. It is …

Healing / tissue repairOral form ~4 hours

TB-500

TB-500 is a synthetic peptide fragment based on the active region of thymosin beta-4, a naturally occurring protein i…

Healing / tissue repairApproximately 2 hours (peptide)

Semaglutide

Semaglutide is a long-acting GLP-1 receptor agonist approved for type 2 diabetes and chronic weight management. It sl…

GLP-1 / metabolicApproximately 7 days (once-weekly dosing)

Tirzepatide

Tirzepatide is a synthetic dual incretin agonist activating both GIP and GLP-1 receptors. Clinical trials show weight…

GLP-1/GIP / metabolicApproximately 5 days (once-weekly dosing)

CJC-1295

CJC-1295 is a synthetic analog of growth-hormone-releasing hormone (GHRH). It stimulates the pituitary to release end…

Growth hormone axisNo-DAC: ~30 minutes

Ipamorelin

Ipamorelin is a selective growth hormone secretagogue that mimics ghrelin at the GHSR-1a receptor. It is prized for s…

Growth hormone axisApproximately 2 hours

GHK-Cu

GHK-Cu is a naturally occurring copper-binding tripeptide with well-studied effects on collagen synthesis, wound heal…

Skin / connective tissueApproximately 0

PT-141

PT-141 (bremelanotide) is a synthetic melanocortin receptor agonist developed from melanotan II. It acts on central n…

Libido / sexual healthApproximately 2 hours

MOTS-c

MOTS-c is a 16-amino-acid peptide encoded within mitochondrial DNA. It is studied for its role in metabolic regulatio…

Metabolic / longevityShort (minutes systemically)

Tesamorelin

Tesamorelin is a stabilized analog of human GHRH, FDA approved for reducing excess visceral adipose tissue in HIV-ass…

Growth hormone axisApproximately 30 minutes

Retatrutide

Retatrutide is an investigational triple agonist at GIP, GLP-1, and glucagon receptors. Phase 2 trial data reported w…

GLP-1/GIP/glucagon / metabolicApproximately 6 days (once-weekly dosing)

Hexarelin

Hexarelin is a synthetic growth-hormone-releasing peptide that stimulates pituitary GH release. It is the most potent…

Growth hormone axisApproximately 70 minutes

MK-677

MK-677 (ibutamoren) is an orally active, non-peptide ghrelin receptor agonist studied for sustained elevation of GH a…

Growth hormone axisApproximately 24 hours (oral)

Selank

Selank is a synthetic heptapeptide modeled on tuftsin. It is studied for anxiolytic, nootropic, and immunomodulatory …

Nootropic / anxiolyticApproximately 30 minutes systemically

Semax

Semax is a synthetic peptide derived from a fragment of adrenocorticotropic hormone (ACTH). It is studied for cogniti…

NootropicShort systemically (minutes)

Epithalon

Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from epithalamin, a pineal gland extract. It is studi…

Longevity / pinealShort systemic half-life

Thymosin Alpha-1

Thymosin Alpha-1 is a natural immunomodulatory peptide originally isolated from the thymus. It is studied for its eff…

ImmunomodulatorApproximately 2 hours

HGH (Somatropin)

Human growth hormone (somatropin) is a recombinant version of endogenous GH. It is FDA approved for several deficienc…

Growth hormoneApproximately 2–4 hours (recombinant, subcutaneous)

IGF-1 LR3

IGF-1 LR3 is a modified analog of insulin-like growth factor 1 with an extended half-life due to reduced IGF-binding-…

IGF / growthApproximately 20–30 hours (substantially extended vs native IGF-1's ~10–20 minutes)

HCG

Human chorionic gonadotropin (HCG) is a glycoprotein hormone that mimics luteinizing hormone (LH). It is used clinica…

Gonadotropin / hormone supportBiphasic: initial ~6 hours, terminal ~36 hours

Sermorelin

Sermorelin is a truncated 29-amino-acid analog of endogenous growth-hormone-releasing hormone (GHRH). It stimulates t…

GH secretagogue (GHRH)Approximately 10–20 minutes

GHRP-2

GHRP-2 is a synthetic ghrelin receptor agonist that strongly stimulates growth hormone release. It is often paired wi…

GH secretagogue (GHRP)Approximately 15–60 minutes

GHRP-6

GHRP-6 is a hexapeptide ghrelin-receptor agonist that strongly stimulates growth-hormone release and appetite. It is …

GH secretagogue (GHRP)Approximately 15–60 minutes

AOD-9604

AOD-9604 is a synthetic fragment of the C-terminal region of human growth hormone (amino acids 176–191). It was devel…

Metabolic / fat lossApproximately 30 minutes (plasma)

Melanotan II

Melanotan II is a synthetic analog of alpha-MSH that stimulates melanogenesis (skin darkening) and is studied for its…

Melanocortin agonistApproximately 33 hours

Kisspeptin-10

Kisspeptin-10 is a short fragment of the kisspeptin protein that acts as the master regulator of the HPG axis. It sti…

Neuroendocrine / HPG axisApproximately 4 minutes (extremely short)

Gonadorelin

Gonadorelin is a synthetic form of endogenous GnRH. It is used in TRT protocols as an HCG alternative to maintain tes…

Gonadotropin / HPG axis2–10 minutes (very short)

DSIP

DSIP is a naturally occurring nonapeptide first isolated from the brains of sleeping rabbits. It is studied for effec…

Sleep / neuromodulatorApproximately 7–15 minutes (very short plasma half-life)

SS-31

SS-31 (elamipretide) is a synthetic tetrapeptide that selectively concentrates in mitochondria, binds cardiolipin on …

Mitochondrial / longevityApproximately 4 hours (subcutaneous)

Liraglutide

Liraglutide is a once-daily GLP-1 receptor agonist FDA approved for type 2 diabetes (Victoza) and chronic weight mana…

Metabolic / GLP-1Approximately 13 hours (once-daily dosing)

Cagrilintide

Cagrilintide is a long-acting amylin analog developed for once-weekly subcutaneous dosing. It is being studied primar…

Metabolic / amylinApproximately 6 days (once-weekly dosing)

Survodutide

Survodutide is a once-weekly dual GLP-1 / glucagon receptor agonist under clinical development for obesity and metabo…

Metabolic / GLP-1Approximately 5 days (once-weekly dosing)

Orforglipron

Orforglipron is an oral non-peptide small-molecule GLP-1 receptor agonist. Unlike semaglutide-in-Rybelsus, orforglipr…

Metabolic / GLP-1Approximately 29–49 hours (once-daily oral dosing)

MOD-GRF (1-29)

MOD-GRF (1-29), also sold as CJC-1295 without DAC, is a stabilized analog of the first 29 amino acids of human GHRH. …

Growth hormone axisApproximately 30 minutes

IGF-1 DES

IGF-1 DES is a truncated variant of IGF-1 (des[1-3]) with reduced IGFBP-3 binding affinity, producing a stronger loca…

Growth hormone axis / IGFApproximately 20–30 minutes

Follistatin-344

Follistatin-344 is a synthetic follistatin peptide that binds and inhibits myostatin and activin, raising the upper c…

Muscle / myostatinApproximately 30 minutes to 2 hours

NAD+

NAD+ (nicotinamide adenine dinucleotide) is an endogenous redox cofactor central to mitochondrial energy production, …

Longevity / mitochondrialApproximately 4–10 minutes (IV)

5-Amino-1MQ

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme implicated in metabol…

Metabolic / NNMTApproximately 5–6 hours (preclinical data)

KPV

KPV is the C-terminal tripeptide (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone (α-MSH). Research focuses on i…

Anti-inflammatory / immuneApproximately 1–2 hours

LL-37

LL-37 is the active C-terminal fragment of the human cathelicidin hCAP-18. It has broad-spectrum antimicrobial activi…

Antimicrobial / immuneApproximately 1–2 hours (plasma)

HGH Fragment 176-191

HGH Fragment 176-191 is a synthetic peptide corresponding to the C-terminal region of human growth hormone. It is stu…

Growth hormone axis / fat lossApproximately 30 minutes

Mechano Growth Factor

Mechano Growth Factor (MGF) is a splice variant of IGF-1 (IGF-1Ec) produced locally in skeletal muscle in response to…

Muscle / IGFApproximately 5–7 minutes (very short)

Cerebrolysin

Cerebrolysin is a neurotrophic peptide preparation derived from pig brain, used clinically outside the US for stroke,…

Neurology / cognitionVariable (peptide mixture, not a single molecule)

Dihexa

Dihexa is an orally bioavailable angiotensin IV analog designed to cross the blood–brain barrier and potentiate hepat…

Cognition / nootropicApproximately 2–3 hours (oral bioavailable)

Glutathione

Glutathione (GSH) is a tripeptide (glutamate-cysteine-glycine) that serves as the cell's primary endogenous antioxida…

Antioxidant / detoxApproximately 10 minutes (IV)

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Educational use only. Peptide Protocol is an informational tool. Nothing on this page constitutes medical advice. Many peptides are prescription-only or restricted in your jurisdiction. Always consult a licensed healthcare professional before injecting any compound.