Follistatin-344: the complete guide
Follistatin-344 is a synthetic follistatin peptide that binds and inhibits myostatin and activin, raising the upper ceiling on muscle growth in preclinical models. Most evidence is from animal studies.
How Follistatin-344 works
Follistatin binds myostatin (GDF-8) and activin A, preventing their signaling through ActRIIB on muscle. Myostatin normally restrains muscle growth; inhibiting it permits hypertrophy beyond typical limits.
Typical Follistatin-344 dosage
Commonly reported research ranges: 100 mcg per injection (research protocols vary widely).
Dose should always be individualized. Factors that influence it include bodyweight, research goal, tolerance, and specific compound batch. The information below is educational, not a prescription.
How to reconstitute Follistatin-344
A widely used reconstitution for a 1 mg vial is 2 ml of bacteriostatic water. With a typical 100 mcg dose this works out to the unit count shown in the calculator below.
Half-life and administration frequency
Approximately 30 minutes to 2 hours.
This half-life informs how often Follistatin-344 is typically dosed. Shorter half-lives usually mean more frequent dosing to maintain plasma levels; longer half-lives allow daily, weekly, or less-frequent administration depending on the compound.
Reported side effects
- Injection-site reactions
- Limited human safety data
- Potential effects on activin-regulated tissues (reproductive, hematopoietic) are incompletely characterized
This list reflects effects reported in available literature or user logs. It is not exhaustive. Adverse reactions should be discussed with a qualified clinician.
Common Follistatin-344 stacks
- HGH
- IGF-1 LR3
Storage and handling
Lyophilized: refrigerated. Reconstituted: refrigerated, use within 14 days.
FDA and regulatory status
Not FDA approved. Research use only in the US.
Follistatin-344 clinical trials and evidence
For clinical-trial and primary-literature context, start with the sources below. We prioritize official drug labels, ClinicalTrials.gov records, and PubMed-indexed literature when available.
- Follistatin gene-therapy trial records — ClinicalTrials.gov
Track your Follistatin-344 protocol on iPhone
Peptide Protocol logs every dose, calculates reconstitution for you, and keeps your full protocol on one calm screen.
See the app →Frequently asked questions
What is Follistatin-344?
Follistatin-344 is a synthetic follistatin peptide that binds and inhibits myostatin and activin, raising the upper ceiling on muscle growth in preclinical models. Most evidence is from animal studies.
How does Follistatin-344 work?
Follistatin binds myostatin (GDF-8) and activin A, preventing their signaling through ActRIIB on muscle. Myostatin normally restrains muscle growth; inhibiting it permits hypertrophy beyond typical limits.
What is a typical Follistatin-344 dose?
Commonly reported ranges are 100 mcg per injection (research protocols vary widely). This is research information, not a recommendation — dosing should be individualized under clinical guidance.
What is the half-life of Follistatin-344?
Approximately 30 minutes to 2 hours. This influences how often it is administered.
How do you reconstitute Follistatin-344?
A common approach is to add 2 ml of bacteriostatic water to a 1 mg vial. Use the reconstitution calculator for exact unit counts.
What are the side effects of Follistatin-344?
Injection-site reactions; Limited human safety data; Potential effects on activin-regulated tissues (reproductive, hematopoietic) are incompletely characterized.
Is Follistatin-344 FDA approved?
Not FDA approved. Research use only in the US.
Are there clinical trials for Follistatin-344?
Registered or published clinical-trial sources for Follistatin-344 are listed in the references section below. Evidence depth varies widely by compound, so check the cited trial registries and primary literature before relying on any claim.
References
- Follistatin / myostatin inhibition literature — National Library of Medicine. Primary research on follistatin-myostatin-activin signaling
- Lee & McPherron — Myostatin and the control of skeletal muscle mass — PubMed. Foundational work on myostatin regulation of muscle growth
- Follistatin gene-therapy trial records — ClinicalTrials.gov. Trials of follistatin gene therapy in muscular dystrophy
Sources listed above were used to verify the claims on this page. See our editorial policy for how we source information.
Educational use only. Peptide Protocol is an informational tool. Nothing on this page constitutes medical advice. Many peptides are prescription-only or restricted in your jurisdiction. Always consult a licensed healthcare professional before injecting any compound.