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Kisspeptin-10: the complete guide

Kisspeptin-10 is a short fragment of the kisspeptin protein that acts as the master regulator of the HPG axis. It stimulates GnRH release and downstream LH, FSH, and sex-hormone production.

Written by Peptide Protocol Editorial Medically reviewed per our review process Last reviewed
ClassKisspeptin receptor agonist (10-amino-acid fragment)
Half-lifeApproximately 4 minutes (extremely short)
Typical dose50–300 mcg per injection in research; clinical IV infusion protocols differ significantly
CategoryNeuroendocrine / HPG axis
Research useHPG axis research, fertility, hypogonadism
FDA statusNot FDA approved. Active clinical research for hypothalamic amenorrhea and fertility.

How Kisspeptin-10 works

Kisspeptin-10 binds the GPR54 (KISS1R) receptor on hypothalamic GnRH neurons, driving pulsatile GnRH release that triggers pituitary gonadotropin secretion.

Typical Kisspeptin-10 dosage

Commonly reported research ranges: 50–300 mcg per injection in research; clinical IV infusion protocols differ significantly.

Dose should always be individualized. Factors that influence it include bodyweight, research goal, tolerance, and specific compound batch. The information below is educational, not a prescription.

How to reconstitute Kisspeptin-10

A widely used reconstitution for a 5 mg vial is 2 ml of bacteriostatic water. With a typical 100 mcg dose this works out to the unit count shown in the calculator below.

Open the Kisspeptin-10 reconstitution calculator →

Pre-filled with the common 5 mg + 2 ml ratio. Adjust for your own vial.

Half-life and administration frequency

Approximately 4 minutes (extremely short).

This half-life informs how often Kisspeptin-10 is typically dosed. Shorter half-lives usually mean more frequent dosing to maintain plasma levels; longer half-lives allow daily, weekly, or less-frequent administration depending on the compound.

Reported side effects

This list reflects effects reported in available literature or user logs. It is not exhaustive. Adverse reactions should be discussed with a qualified clinician.

Common Kisspeptin-10 stacks

Storage and handling

Lyophilized refrigerated. Reconstituted: refrigerated, use within 14 days (peptide is fragile).

FDA and regulatory status

Not FDA approved. Active clinical research for hypothalamic amenorrhea and fertility.

Kisspeptin-10 clinical trials and evidence

For clinical-trial and primary-literature context, start with the sources below. We prioritize official drug labels, ClinicalTrials.gov records, and PubMed-indexed literature when available.

Track your Kisspeptin-10 protocol on iPhone

Peptide Protocol logs every dose, calculates reconstitution for you, and keeps your full protocol on one calm screen.

See the app →

Frequently asked questions

What is Kisspeptin-10?

Kisspeptin-10 is a short fragment of the kisspeptin protein that acts as the master regulator of the HPG axis. It stimulates GnRH release and downstream LH, FSH, and sex-hormone production.

How does Kisspeptin-10 work?

Kisspeptin-10 binds the GPR54 (KISS1R) receptor on hypothalamic GnRH neurons, driving pulsatile GnRH release that triggers pituitary gonadotropin secretion.

What is a typical Kisspeptin-10 dose?

Commonly reported ranges are 50–300 mcg per injection in research; clinical IV infusion protocols differ significantly. This is research information, not a recommendation — dosing should be individualized under clinical guidance.

What is the half-life of Kisspeptin-10?

Approximately 4 minutes (extremely short). This influences how often it is administered.

How do you reconstitute Kisspeptin-10?

A common approach is to add 2 ml of bacteriostatic water to a 5 mg vial. Use the reconstitution calculator for exact unit counts.

What are the side effects of Kisspeptin-10?

Headache; Injection-site reactions; Transient flushing; Safety profile in long-term use not fully characterized.

Is Kisspeptin-10 FDA approved?

Not FDA approved. Active clinical research for hypothalamic amenorrhea and fertility.

Are there clinical trials for Kisspeptin-10?

Registered or published clinical-trial sources for Kisspeptin-10 are listed in the references section below. Evidence depth varies widely by compound, so check the cited trial registries and primary literature before relying on any claim.

References

  1. Kisspeptin literature (PubMed) — National Library of Medicine. Primary research on kisspeptin as a key upstream regulator of the HPG axis
  2. Dhillo et al. — Kisspeptin in human reproduction — PubMed. Key translational work on kisspeptin-54 and GnRH/LH secretion in humans
  3. Kisspeptin clinical trial records — ClinicalTrials.gov. Registered trials across reproductive and fertility indications

Sources listed above were used to verify the claims on this page. See our editorial policy for how we source information.

Educational use only. Peptide Protocol is an informational tool. Nothing on this page constitutes medical advice. Many peptides are prescription-only or restricted in your jurisdiction. Always consult a licensed healthcare professional before injecting any compound.