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Hexarelin: the complete guide

Hexarelin is a synthetic growth-hormone-releasing peptide that stimulates pituitary GH release. It is the most potent GH-releasing peptide per mcg but shows tachyphylaxis with continuous use.

Written by Peptide Protocol Editorial Medically reviewed per our review process Last reviewed
ClassGrowth-hormone-releasing peptide (GHRP-6 analog)
Half-lifeApproximately 70 minutes
Typical dose100 mcg, 1–3x daily
CategoryGrowth hormone axis
Research useGH pulse research, short-cycle protocols
FDA statusNot FDA approved. Research use only.

How Hexarelin works

Hexarelin activates the ghrelin / GHSR-1a receptor, triggering strong GH pulses. Unlike ipamorelin, hexarelin also modestly elevates cortisol and prolactin.

Typical Hexarelin dosage

Commonly reported research ranges: 100 mcg, 1–3x daily.

Dose should always be individualized. Factors that influence it include bodyweight, research goal, tolerance, and specific compound batch. The information below is educational, not a prescription.

How to reconstitute Hexarelin

A widely used reconstitution for a 2 mg vial is 2 ml of bacteriostatic water. With a typical 100 mcg dose this works out to the unit count shown in the calculator below.

Open the Hexarelin reconstitution calculator →

Pre-filled with the common 2 mg + 2 ml ratio. Adjust for your own vial.

Half-life and administration frequency

Approximately 70 minutes.

This half-life informs how often Hexarelin is typically dosed. Shorter half-lives usually mean more frequent dosing to maintain plasma levels; longer half-lives allow daily, weekly, or less-frequent administration depending on the compound.

Reported side effects

This list reflects effects reported in available literature or user logs. It is not exhaustive. Adverse reactions should be discussed with a qualified clinician.

Common Hexarelin stacks

Storage and handling

Lyophilized refrigerated. Reconstituted: refrigerated, use within 28 days.

FDA and regulatory status

Not FDA approved. Research use only.

Hexarelin clinical trials and evidence

For clinical-trial and primary-literature context, start with the sources below. We prioritize official drug labels, ClinicalTrials.gov records, and PubMed-indexed literature when available.

Track your Hexarelin protocol on iPhone

Peptide Protocol logs every dose, calculates reconstitution for you, and keeps your full protocol on one calm screen.

See the app →

Frequently asked questions

What is Hexarelin?

Hexarelin is a synthetic growth-hormone-releasing peptide that stimulates pituitary GH release. It is the most potent GH-releasing peptide per mcg but shows tachyphylaxis with continuous use.

How does Hexarelin work?

Hexarelin activates the ghrelin / GHSR-1a receptor, triggering strong GH pulses. Unlike ipamorelin, hexarelin also modestly elevates cortisol and prolactin.

What is a typical Hexarelin dose?

Commonly reported ranges are 100 mcg, 1–3x daily. This is research information, not a recommendation — dosing should be individualized under clinical guidance.

What is the half-life of Hexarelin?

Approximately 70 minutes. This influences how often it is administered.

How do you reconstitute Hexarelin?

A common approach is to add 2 ml of bacteriostatic water to a 2 mg vial. Use the reconstitution calculator for exact unit counts.

What are the side effects of Hexarelin?

Cortisol elevation; Prolactin elevation; Tachyphylaxis with sustained use; Injection-site reactions.

Is Hexarelin FDA approved?

Not FDA approved. Research use only.

Are there clinical trials for Hexarelin?

Registered or published clinical-trial sources for Hexarelin are listed in the references section below. Evidence depth varies widely by compound, so check the cited trial registries and primary literature before relying on any claim.

References

  1. Hexarelin literature (PubMed) — National Library of Medicine. Primary studies on hexarelin GH secretion and cardiovascular effects
  2. Ghigo et al. — Growth hormone-releasing activity of hexarelin in humans — PubMed. Human GH-release pharmacology of hexarelin
  3. Hexarelin clinical trial records — ClinicalTrials.gov. Registered human studies

Sources listed above were used to verify the claims on this page. See our editorial policy for how we source information.

Educational use only. Peptide Protocol is an informational tool. Nothing on this page constitutes medical advice. Many peptides are prescription-only or restricted in your jurisdiction. Always consult a licensed healthcare professional before injecting any compound.