Sermorelin + GHRP-2: the stack guide

Sermorelin and GHRP-2 are an older, well-characterized GHRH + GHRP pair — the precursor to the CJC-1295/Ipamorelin combo. Still used clinically because both have decades of human safety data and Sermorelin in particular has FDA history.

Typical protocol is 100–300 mcg Sermorelin plus 100 mcg GHRP-2, injected subcutaneously together pre-bed. The shorter half-life of Sermorelin means the GH pulse is more time-locked than with CJC-1295 — better for users who specifically want a single sleep-onset spike.

Many users co-administer GHRH + GHRP pairs (like CJC-1295 + Ipamorelin) in a single syringe to reduce injections, since both are stable in bacteriostatic water for short periods. For other pairs, draw and inject separately to minimize compatibility risk and to attribute any reaction to the correct compound.

GHRP-2 raises cortisol and prolactin more than Ipamorelin does — not dramatically, but enough that some users prefer the cleaner Ipamorelin profile. Hunger, flushing, and head-rush at injection are common. Long-term use should be cycled.

Most user-reported cycles run 4–12 weeks depending on the goal. GH-axis stacks are typically cycled with a break of 4 weeks or more between blocks to preserve receptor sensitivity. Soft-tissue stacks are usually run continuously until the injury resolves.